From the 1950s onwards, were all in favor of raising the standards of animal models because as a branch of science, leading to improved quality and animal welfare were tested. The definition of the concept of the welfare of fish compared to other animals, it is difficult but it can be described as an attempt to provide health conditions to fish a natural characteristic behavioral, social and physiological of the show. Over the past 30 years, an important debate about the ability of fish to understand the stress, suffering, hardship, fear or pain there. In addition, it has been shown that fish can remember the negative experiences which, behavioral and cognitive capacity for processing fish and show the right reaction. Responsible for conducting animal research is required in addition to recognizing and respecting the rights of animals, nature and spirit of the rules is to minimize the use of animals and enhance the quality of life of an animal subject, more of interest to researchers, managers and stakeholders be.