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Spirulina- and brittle star-derived bioactive compounds: Emerging opportunities for wound healing and tissue regeneration in ornamental fish
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S. Karchin *   , R. Manaffar , A. Imani , M. Niko |
| Department of Fisheries, Faculty of Natural Resources, Urmia University, Urmia, Iran |
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Abstract: (4 Views) |
| Wound healing and tissue regeneration are essential biological processes for maintaining the health, welfare, and survival of ornamental fish, particularly under conditions associated with high stocking densities, transportation stress, aggressive interactions, skin diseases, and mechanical injuries. In recent years, increasing attention has been directed toward the use of natural bioactive compounds to enhance tissue repair and regenerative responses in aquatic organisms. Among the promising sources of such compounds are the microalga Limnospira platensis (Spirulina) and brittle stars, both of which contain a wide range of biologically active molecules with potential applications in regenerative aquaculture. Numerous studies have demonstrated that phycocyanin, polysaccharides, bioactive peptides, and other Spirulina-derived metabolites can promote wound healing by reducing oxidative stress, modulating inflammatory responses, stimulating cellular proliferation and migration, and enhancing collagen synthesis. Similarly, bioactive compounds isolated from brittle stars have shown considerable potential to support tissue regeneration through the activation of angiogenic pathways, cellular differentiation, and tissue remodeling processes. In addition, the antioxidant, antimicrobial, and immunomodulatory properties of these compounds may contribute to the management of wounds and common lesions in ornamental fish. This review summarizes the major bioactive compounds derived from Spirulina and brittle stars, while also briefly addressing other marine-derived biomaterials such as sea cucumbers, chitin, and chitosan. The molecular and cellular mechanisms underlying their regenerative activities are discussed, together with their potential applications, current limitations, and future prospects for use in ornamental fish health management and regenerative aquaculture. |
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| Keywords: Wound healing, Tissue regeneration, Ornamental fish, Spirulina, Brittle stars, Bioactive compounds, Regenerative medicine, Aquatic animal health. |
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Full-Text [PDF 587 kb]
(2 Downloads)
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Type of Study: Research |
Subject:
Special
Received: 2026/06/2 | Accepted: 2026/07/1 | Published: 2026/07/1
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