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Subacute Effects of Titanium Dioxide Nanoparticles on Physiological Stress Markers in Platy Fish (Xiphophorus maculatus)
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Mohsen Miri   , Seraj Bita * |
| Chabahar maritime university |
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Abstract: (8 Views) |
| Titanium dioxide nanoparticles (TiO₂ NPs), widely used in industrial and personal care products, are increasingly detected in aquatic systems, raising concerns about their physiological impacts on fish. This study assessed the subacute toxicity of TiO₂ NPs in platy fish (Xiphophorus maculatus) during a 21-day exposure. Fish (2.65 ± 0.45 g) were exposed to five concentrations corresponding to 10, 15, 25, 50, and 75% of the 96-h LC₅₀, with a nanoparticle-free group serving as the control. Exposure to TiO₂ NPs caused significant elevations in plasma cortisol and glucose (p<0.05), indicating activation of the hypothalamic–pituitary–interrenal axis and metabolic stress. Lactate levels showed no significant alteration (p>0.05), implying limited involvement of anaerobic pathways. Overall, the findings suggest that environmentally relevant TiO₂ NP concentrations can disrupt physiological homeostasis in platy fish and may pose risks to fish health in contaminated habitats. |
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| Keywords: Titanium dioxide nanoparticles, Subacute toxicity, Stress biomarkers, Cortisol, Glucose, Xiphophorus maculatus |
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Full-Text [PDF 558 kb]
(4 Downloads)
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Type of Study: Research |
Subject:
Special
Received: 2025/09/19 | Accepted: 2025/12/31 | Published: 2025/12/31
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