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Review article: A comprehensive review of the molecular development of zebrafish (Danio rerio)
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Sh. Hasanpour   , S. Eagderi * , S. Eagderi |
| Department of Fisheries, Faculty of Natural Resources, University College of Agriculture and Natural Resources, University of Tehran, University of Tehran, Karaj, Iran |
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Abstract: (148 Views) |
Despite the extensive use of zebrafish (Danio rerio) as a model organism, a unified source detailing its molecular development remains lacking, particularly regarding germ layer formation and axis patterning. This review provides a comprehensive overview of the molecular mechanisms underlying zebrafish development. Following fertilization, the zygotic genome remains transcriptionally inactive, and maternally deposited factors determine the precise positioning of zygotically active signaling centers that guide body axis formation and patterning. The dorsal and ventral signaling centers antagonize one another to establish the dorsal–ventral (D/V) axis. Their interaction gives rise to inductive morphogen fields composed of Bmps, Wnts, Fgf, and Squint, which generate concentration gradients that specify distinct mesendodermal and ectodermal cell fates along the D/V axis, ultimately shaping the body plan (fate map). Along the animal–vegetal axis, a decreasing gradient of Squint toward the animal pole contributes to the sequential specification of endoderm, mesoderm, and ectoderm. According to this model, high levels of Squint promote endoderm formation, lower levels drive mesodermal development, and its absence permits ectoderm specification.
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| Keywords: Zebrafish, Dorsal organizer, Ventral center, Axis patterning |
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Full-Text [PDF 804 kb]
(59 Downloads)
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Type of Study: Research |
Subject:
Special
Received: 2025/09/30 | Accepted: 2025/09/1 | Published: 2025/09/1
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