Zebrafish as a model in geno toxicology The easiness and low cost of maintenance, high fertility, complete availability of genome sequencing, convenient manipulation, homologation of many genes of zebra fish with mammals and the presence of mutant strains of this fish has changed this species to a popular fish in biology, medical and genetic research. Geno toxicology is a science that studies the effects of pollutants on the genome level of organisms. Many studies have been done using this model to evaluate reproductive performance, immune systems and antioxidants at the genome level. This paper reviews the use of this model fish in aquatic geno toxicology studies, which can be considered in human medical issues.