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Dietary oregano extract (Origanum vulgare L.) improves growth performance and alleviates histopathological alterations in the intestine and liver of koi fish (Cyprinus carpio) under long-term naproxen exposure
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چکیده: (9 مشاهده) |
Pharmaceutical contaminants in aquatic environments are an increasing ecological concern that adversely affect aquaculture production, resulting in reduced productivity and substantial economic losses. This study evaluated the protective role of oregano essential oil (OEO) supplementation on growth performance and histopathological changes in koi fish (Cyprinus carpio) subjected to long-term exposure to naproxen (NPX). A total of 180 fish were randomly assigned to four treatment groups: control, OEO-fed, NPX-exposed, and combined OEO-fed/NPX-exposed. The findings revealed that OEO supplementation significantly enhanced growth performance by increasing intestinal villus length and thickness, as well as the number of goblet cells, indicating improved nutrient absorption and intestinal health. In contrast, NPX exposure induced marked hepatic and intestinal lesions, such as villus corruption, vacuolation, hyperemia, villus adhesion, and cellular necrosis. Notably, these pathological alterations were substantially alleviated in the OEO-fed group, demonstrating the protective efficacy of OEO. Overall, dietary supplementation with OEO offers a promising natural strategy to counteract the adverse impacts of pharmaceutical pollutants on fish health, with potential benefits for sustainable aquaculture.
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متن کامل [PDF 739 kb]
(4 دریافت)
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نوع مطالعه: پژوهشي |
موضوع مقاله:
تخصصي
دریافت: 1404/6/16 | پذیرش: 1404/7/10 | انتشار: 1404/6/16
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