Ornamental Aquatics

fa Review article: A comprehensive review of the molecular development of zebrafish (Danio rerio) Review article: A comprehensive review of the molecular development of zebrafish (Danio rerio) تخصصي Special پژوهشي Research <a name="_Hlk207021807">Despite the extensive use of zebrafish (Danio rerio) as a model organism, a unified source detailing its molecular development remains lacking, particularly regarding germ layer formation and axis patterning. This review provides a comprehensive overview of the molecular mechanisms underlying zebrafish development. </a>Following fertilization, the zygotic genome remains transcriptionally inactive, and maternally deposited factors determine the precise positioning of zygotically active signaling centers that guide body axis formation and patterning. The dorsal and ventral signaling centers antagonize one another to establish the dorsal–ventral (D/V) axis. Their interaction gives rise to inductive morphogen fields composed of Bmps, Wnts, Fgf, and Squint, which generate concentration gradients that specify distinct mesendodermal and ectodermal cell fates along the D/V axis, ultimately shaping the body plan (fate map). Along the animal–vegetal axis, a decreasing gradient of Squint toward the animal pole contributes to the sequential specification of endoderm, mesoderm, and ectoderm. According to this model, high levels of Squint promote endoderm formation, lower levels drive mesodermal development, and its absence permits ectoderm specification.   <a name="_Hlk207021807">Despite the extensive use of zebrafish (Danio rerio) as a model organism, a unified source detailing its molecular development remains lacking, particularly regarding germ layer formation and axis patterning. This review provides a comprehensive overview of the molecular mechanisms underlying zebrafish development. </a>Following fertilization, the zygotic genome remains transcriptionally inactive, and maternally deposited factors determine the precise positioning of zygotically active signaling centers that guide body axis formation and patterning. The dorsal and ventral signaling centers antagonize one another to establish the dorsal–ventral (D/V) axis. Their interaction gives rise to inductive morphogen fields composed of Bmps, Wnts, Fgf, and Squint, which generate concentration gradients that specify distinct mesendodermal and ectodermal cell fates along the D/V axis, ultimately shaping the body plan (fate map). Along the animal–vegetal axis, a decreasing gradient of Squint toward the animal pole contributes to the sequential specification of endoderm, mesoderm, and ectoderm. According to this model, high levels of Squint promote endoderm formation, lower levels drive mesodermal development, and its absence permits ectoderm specification.   Zebrafish, Dorsal organizer, Ventral center, Axis patterning Zebrafish, Dorsal organizer, Ventral center, Axis patterning 49 66 http://ornamentalaquatics.ir/browse.php?a_code=A-10-1-90&slc_lang=fa&sid=1 Sh. Hasanpour Sh. Hasanpour 10031947532846003532 10031947532846003532 No Department of Fisheries, Faculty of Natural Resources, University College of Agriculture and Natural Resources, University of Tehran, University of Tehran, Karaj, Iran Department of Fisheries, Faculty of Natural Resources, University College of Agriculture and Natural Resources, University of Tehran, University of Tehran, Karaj, Iran S. Eagderi S. Eagderi 10031947532846003533 10031947532846003533 Yes Department of Fisheries, Faculty of Natural Resources, University College of Agriculture and Natural Resources, University of Tehran, University of Tehran, Karaj, Iran Department of Fisheries, Faculty of Natural Resources, University College of Agriculture and Natural Resources, University of Tehran, University of Tehran, Karaj, Iran S. Eagderi S. Eagderi 10031947532846003534 10031947532846003534 No School of Medicine, Alborz University of Medical Sciences, Karaj, Iran School of Medicine, Alborz University of Medical Sciences, Karaj, Iran