Ornamental Aquatics

fa Dietary oregano extract (Origanum vulgare L.) improves growth performance and alleviates histopathological alterations in the intestine and liver of koi fish (Cyprinus carpio) under long-term naproxen exposure Dietary oregano extract (Origanum vulgare L.) improves growth performance and alleviates histopathological alterations in the intestine and liver of koi fish (Cyprinus carpio) under long-term naproxen exposure تخصصي Special پژوهشي Research <div dir="ltr" style="text-align: justify;">Pharmaceutical contaminants in aquatic environments are an increasing ecological concern that adversely affect aquaculture production, resulting in reduced productivity and substantial economic losses. This study evaluated the protective role of oregano essential oil (OEO) supplementation on growth performance and histopathological changes in koi fish (Cyprinus carpio) subjected to long-term exposure to naproxen (NPX). A total of 180 fish were randomly assigned to four treatment groups: control, OEO-fed, NPX-exposed, and combined OEO-fed/NPX-exposed. The findings revealed that OEO supplementation significantly enhanced growth performance by increasing intestinal villus length and thickness, as well as the number of goblet cells, indicating improved nutrient absorption and intestinal health. In contrast, NPX exposure induced marked hepatic and intestinal lesions, such as villus corruption, vacuolation, hyperemia, villus adhesion, and cellular necrosis. Notably, these pathological alterations were substantially alleviated in the OEO-fed group, demonstrating the protective efficacy of OEO. Overall, dietary supplementation with OEO offers a promising natural strategy to counteract the adverse impacts of pharmaceutical pollutants on fish health, with potential benefits for sustainable aquaculture.  </div> Pharmaceutical contaminants in aquatic environments are an increasing ecological concern that adversely affect aquaculture production, resulting in reduced productivity and substantial economic losses. This study evaluated the protective role of oregano essential oil (OEO) supplementation on growth performance and histopathological changes in koi fish (Cyprinus carpio) subjected to long-term exposure to naproxen (NPX). A total of 180 fish were randomly assigned to four treatment groups: control, OEO-fed, NPX-exposed, and combined OEO-fed/NPX-exposed. The findings revealed that OEO supplementation significantly enhanced growth performance by increasing intestinal villus length and thickness, as well as the number of goblet cells, indicating improved nutrient absorption and intestinal health. In contrast, NPX exposure induced marked hepatic and intestinal lesions, such as villus corruption, vacuolation, hyperemia, villus adhesion, and cellular necrosis. Notably, these pathological alterations were substantially alleviated in the OEO-fed group, demonstrating the protective efficacy of OEO. Overall, dietary supplementation with OEO offers a promising natural strategy to counteract the adverse impacts of pharmaceutical pollutants on fish health, with potential benefits for sustainable aquaculture.   Koi fish, Oregano essential oil, Naproxen, Growth performance, Histopathological changes Koi fish, Oregano essential oil, Naproxen, Growth performance, Histopathological changes 1 15 http://ornamentalaquatics.ir/browse.php?a_code=A-10-1-86&slc_lang=fa&sid=1 K. Jafari K. Jafari 10031947532846003504 10031947532846003504 No Department of Veterinary, Garmsar Branch, Islamic Azad University, Garmsar, Iran Department of Veterinary, Garmsar Branch, Islamic Azad University, Garmsar, Iran M. Mehdipour M. Mehdipour 10031947532846003505 10031947532846003505 Yes Department of Veterinary, Garmsar Branch, Islamic Azad University, Garmsar, Iran Department of Veterinary, Garmsar Branch, Islamic Azad University, Garmsar, Iran F. Firouzbakhsh F. Firouzbakhsh 10031947532846003506 10031947532846003506 No Department of Fisheries, Faculty of Animal Science and Fisheries, Sari Agricultural Sciences and Natural Resources University (SANRU), Sari, Iran Department of Fisheries, Faculty of Animal Science and Fisheries, Sari Agricultural Sciences and Natural Resources University (SANRU), Sari, Iran R. Kazempoor R. Kazempoor 10031947532846003507 10031947532846003507 No Department of Veterinary Hygine, SR.C., Islamic Azad University, Tehran - IRAN. Department of Veterinary Hygine, SR.C., Islamic Azad University, Tehran - IRAN. Sh. Alavinejad Sh. Alavinejad 10031947532846003508 10031947532846003508 No Department of Aquatic Health and Diseases, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran. Department of Aquatic Health and Diseases, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.