he use of nano-technology and nano-enabled products in the industry is the widely expanding. The nanoparticles used in aquaculture in order to cure disease and to control the bacterial load of water can be verified. Nanotechnology is the use of nano-scale structures (at least one Bd100-1 nm), respectively. So that the scale has a wide application in science, chemistry, biology and medicine. Today, with the increasing development of nanotechnology much concern about the potential risks of nanoparticles containing materials release to the environment has been created. So that the release of these substances into the aquatic ecosystems can have undesirable effects on their life species. To evaluate the toxicity of environmental pollutants in fish are different physiological parameters such as including histology. According to the research of nanoparticles affect the tissues of the skin, gills and liver, kidney and intestines is. In this study, the effects of nanoparticles on various of fishs tissues are examined.